منابع مشابه
Stroke-related translational research.
Stroke-related translational research is multifaceted. Herein, we highlight genome-wide association studies and genetic studies of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, COL4A1 mutations, and cerebral cavernous malformations; advances in molecular biology and biomarkers; newer brain imaging research; and recovery from stroke emphasizing cell-...
متن کاملPathophysiological basis of translational stroke research.
The high incidence and the devastating consequences of stroke call for efficient therapies but despite extensive experimental evidence of neuroprotective improvements, most clinical treatments have failed. The poor translational success is attributed to the inappropriate selection of clinically irrelevant animal models, the inappropriate focus on clinically irrelevant injury pathways and the in...
متن کاملTranslational Stroke Research: Vision and Opportunities.
1) To review existing animal models and outcome measures and establish a vision on what is needed to move translational research forward in ischemic and hemorrhagic stroke. 2) To evaluate potential infrastructures and approaches for preclinical studies with a rigorous experimental design with similar standards applied in human clinical trials. 3) Perspectives from Stroke-NET regarding opportuni...
متن کاملMechanisms and challenges in translational stroke research.
Translating basic science advances into clinical meaning has been challenging for stroke research. This does not, however, mean that the investigation of basic mechanisms is irrelevant. Translation is difficult because the underlying mechanisms are complex and ill-defined. The original focus on neuroprotection has now evolved into a broader consideration of the role of non-neuronal cells in str...
متن کاملPotential molecular targets for translational stroke research.
The stroke research community is currently at a crossroads, and a shift in focus is necessary to propel basic research forward to develop clinically effective therapeutics. In-depth analysis of the past failures and imposing more stringent standards on future basic research experiments will greatly improve the success of translational research. The purpose of this review is to outline proposed ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2017
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.117.017112